Skip to content

Evaluation of the effect of Tocilizumab on outcomes of the severe COVID-19 patients

Evaluation of the effect of Tocilizumab on outcomes of the severe COVID-19, determining indications within the paradigm of host-directed therapy

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200510047383N1
Enrollment
100
Registered
2020-05-15
Start date
2020-05-21
Completion date
Unknown
Last updated
2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

covid-19 disease. covid-19 disease

Interventions

Intervention 1: Intervention group: Take tocilizumab. This group is given a dose of 8 mg per kilogram of body weight tocilizumab up to a maximum dose of 800 mg. If the symptoms worsen or do not improv

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: COVID-19 disease confirmed by chest ct and PCR No pregnancy No breastfeeding Negative PPD No bacterial pneumonia (negative sputum and urine culture) Not use of atorvastatin , alprazolam , amlodipine , MTX , hydroxychloroquine , Informed consent

Exclusion criteria

Exclusion criteria: Disapproval of covid-19 disease by chest computed tomography and PCR Positive PPD Bacterial pneumonia (negative sputum and urine culture) Pregnancy Breastfeeding Use of atorvastatin , alprazolam , amlodipine , MTX , hydroxychloroquine by the patient Lack of Informed consent

Design outcomes

Primary

MeasureTime frame
Investigation of mortality rate of CIVID-19 patients. Timepoint: After treatment. Method of measurement: Situation of the patient's life.

Secondary

MeasureTime frame
The average number of hospitalization days for COVID-19 patients. Timepoint: End of treatment. Method of measurement: Day.;Average platelets count. Timepoint: Before and after treatment. Method of measurement: Complete Blood Count (CBC) test.;Average percentage of oxygen saturation. Timepoint: Every 12 hours. Method of measurement: Puls oximeter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammadreza Bozorgmanesh

Arak University of Medical Sciences

mhmmdrz_bzrgmnsh@yahoo.com+98 86 3223 1350

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026