COVID-19 pneumonia. Pneumonia due to SARS-associated coronavirus
Conditions
Interventions
Intervention group: Low dose RT.
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Confirmed COVID-19 diagnosis ( PCR or serologic) Presence of pulmonary involvement ( defined by P/F ratio or NIV need) Less than 3 days since the onset of ARDS Age > 60 years ? IL-6 ( if available) ? CRP
Exclusion criteria
Exclusion criteria: Lack of informed consent Inability to transfer to the radiation unit Hemodynamic instability Septic shock and organ dysfunction Severe ARDS P/F ratio = 100 mmHg History of cardiac failure Contraindications to radiation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase in arterial oxygen pressure. Timepoint: day 1,2,3,4,5,6,7,14,21,28 post treatment. Method of measurement: Blood sample. | — |
Secondary
| Measure | Time frame |
|---|---|
| P/F ratio. Timepoint: day 1,2,3,4,5,6,7,21,28. Method of measurement: Blood gas analysis.;Hs-CRP. Timepoint: day 1,2,3,4,5,6,7,21,28. Method of measurement: blood sample.;IL-6 serum level. Timepoint: day 1,4,7,21,28. Method of measurement: blood sample.;ESR. Timepoint: day 1,2,3,4,5,6,7,14,21,28. Method of measurement: Blood sample. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNazanin Rahnama
Shahid Beheshti University of Medical Sciences
Outcome results
None listed