Effectiveness of Plasmaphersis on the treatment of paraquat poisoned patients

Investigating the effectiveness of plasmapheresis in treatment, hemodynamic, electrolyte parameters and the outcome of paraquat poisoned patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200507047344N4

Enrollment

Registered

2022-07-11

Start date

2022-08-22

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paraquat poisoning. Toxic effect of herbicides and fungicides, accidental (unintentional)

Interventions

Intervention 1: Control group: In this group, patients undergoing routine treatment including hemodialysis and administration of antioxidants including N-acetylcysteine 300 mg/kg 24-hour daily infusio

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 18 years Oral paraquat poisoning (confirmation of paraquat poisoning is determined by testing for urinary sodium dithionate test) No more than 24 hours after poisoning Satisfaction to participate in the study

Exclusion criteria

Exclusion criteria: Having coagulation disorders Having a history of respiratory-lung diseases Having a previous lung injury Having seizures, loss of consciousness or coma

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Before the intervention and the first, third, fifth days after the intervention and during the discharge from the hospital. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: Before the intervention and the first, third, fifth days after the intervention and during the discharge from the hospital. Method of measurement: Monitoring device.;Electrolytic parameters. Timepoint: Before the intervention and the first, third, fifth days after the intervention and during the discharge from the hospital. Method of measurement: Blood test.;Coagulation parameters. Timepoint: Before the intervention and the first, third, fifth days after the intervention and during the discharge from the hospital. Method of measurement: Blood test.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before the intervention and the first, third, fifth days after the intervention and during the discharge from the hospital. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: Before the intervention and the first, third, fifth days after the intervention and during the discharge from the hospital. Method of measurement: Monitoring device.;Electrolytic parameters. Timepoint: Before the intervention and the first, third, fifth days after the intervention and during the discharge from the hospital. Method of measurement: Blood test.;Coagulation parameters. Timepoint: Before the intervention and the first, third, fifth days after the intervention and during the discharge from the hospital. Method of measurement: Blood test.

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Secondary

Measure	Time frame
Tachypnea. Timepoint: The first, third, fifth days after the intervention until discharge from the hospital. Method of measurement: Clinical examination.;Respiratory distress. Timepoint: The first, third, fifth days after the intervention until discharge from the hospital. Method of measurement: Clinical examination.;Hypocalcemia. Timepoint: The first, third, fifth days after the intervention until discharge from the hospital. Method of measurement: Clinical examination.	—

Measure

Time frame

Tachypnea. Timepoint: The first, third, fifth days after the intervention until discharge from the hospital. Method of measurement: Clinical examination.;Respiratory distress. Timepoint: The first, third, fifth days after the intervention until discharge from the hospital. Method of measurement: Clinical examination.;Hypocalcemia. Timepoint: The first, third, fifth days after the intervention until discharge from the hospital. Method of measurement: Clinical examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShafeajafar Zoofaghari

Esfahan University of Medical Sciences

shafeajafar@med.mui.ac.ir+98 31 3268 7610

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026