Methadone poisoning. Toxic effect of methanol, accidental (unintentional)
Conditions
Interventions
Intervention 1: Intervention group: For all patients, methylprednisolone 250 mg every 6 hours to 3 days (equivalent to 1 gram daily for 3 days) is administered as an intravenous infusion (in normal sa
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 60 Years
Inclusion criteria
Inclusion criteria: Diagnosis of methanol poisoning No more toxicity through history and negative urine tests for toxicology Having a blurred vision or visual impairment in any form Age range 15 to 60 years Poisoning less than 72 hours before arrival at the hospital Failure to perform cardiopulmonary resuscitation at admission No coma for the patient before entering the study (having a level of consciousness) Consent to participate in the study
Exclusion criteria
Exclusion criteria: People with melatonin contraindications Having sensitive to melatonin Loss of consciousness Having a severe chronic illness (including high blood pressure, liver cirrhosis, congestive heart failure (CHF), chronic respiratory disease, end-stage kidney disease, or a high-risk immune condition (leukemia, lymphoma, or AIDS))
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seizures. Timepoint: Upon arrival at the hospital and one week after the intervention. Method of measurement: Observational.;Abnormal CT scan of the brain. Timepoint: Upon arrival at the hospital and one week after the intervention. Method of measurement: Observational.;Visual disorders. Timepoint: 1, 5 and 10 days during the intervention and one week after the intervention. Method of measurement: Ophthalmological examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShafeajafar Zoofaghari
Esfahan University of Medical Sciences
Outcome results
None listed