The effect of statins on surgical site infection

The effect of statins on surgical site infection after open-heart surgery: a double-blind, randomized, placebo-controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200507047327N2

Enrollment

300

Registered

2021-06-27

Start date

2021-10-23

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infection. Bacterial infection, unspecified

Interventions

Intervention 1: Intervention group: Patients will receive a daily 40 mg tablet of rosuvastatin (Abaidi Company) for 10 days orally, from the day before open-heart surgery. Intervention 2: Control gro

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who are candidates for open-heart surgery Patients who are not receiving any type of statin medications before the open-heart surgery

Exclusion criteria

Exclusion criteria: Patients who are susceptible to infection such as those with immunodeficiencies patients with signs of infection before the surgery

Design outcomes

Primary

Measure	Time frame
Surgical site infection. Timepoint: 10 days after heart surgery. Method of measurement: Observation and if signs of infection were observed culture from the site of infection.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamira Hossaini Alhashemi

Shiraz University of Medical Sciences

shossaini@sums.ac.ir+98 71 3242 4127

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026