effect of curcumin on prevention of atrial fibrillation after coronary artery bypass graft surgery

The effect of nano-curcumin on prevention of atrial fibrillation after coronary artery bypass graft surgery: a double-blind, randomized, placebo-controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200507047327N1

Enrollment

200

Registered

2020-07-21

Start date

2020-06-25

Completion date

Unknown

Last updated

2020-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiac disease. Atherosclerotic heart disease of native coronary artery

Interventions

Intervention 1: Intervention group: took 80 mg of curcumin-containing soft-gel nanomicell capsules three times a day for three days before surgery and five days after surgery with a standard medicati

Eligibility

Sex/Gender

All

Age

18 Years to 82 Years

Inclusion criteria

Inclusion criteria: Patients who are candidates for open heart surgery No history of cardiac surgery patients use ACE/ ARB, beta blocker, statin, ASA

Exclusion criteria

Exclusion criteria: history of Cardiac arrhythmias or taking antiarrhythmic drugs use digoxin Heart valve disorders Heart failure and EF = 30% Renal failure (creatinine = 1.5) Severe hepatic insufficiency (increased liver enzymes more than 3 times normal) Sensitivity to turmeric

Design outcomes

Primary

Measure	Time frame
Condition of Atrial fibrillation arrhythmia. Timepoint: five days after open heart surgery. Method of measurement: 24-hour monitoring of the patient by ECG.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamira Hossaini Alhashemi

Shiraz University of Medical Sciences

shossaini@sums.ac.ir+98 71 3242 5305

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026