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epinephrine in COVID-19

Evaluation of the effects of epinephrine on the treatment of COVID-19 pneumonia: a randomized clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200506047323N8
Enrollment
84
Registered
2021-05-24
Start date
2021-06-05
Completion date
Unknown
Last updated
2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19, virus identified. COVID-19, virus identified

Interventions

Intervention 1: Intervention group: The standard treatment for COVID-19 based on the Ministry of Health's protocol plus intratracheal epinephrine for intubated patients, and nebulizer form of epinephr

Sponsors

Bandare-abbas University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Months

Inclusion criteria

Inclusion criteria: Age between 18 and 80 years Positive polymerase chain reaction (PCR) test for COVID-19 Hospitalized Signing informed consent and willingness of study participant to accept randomization to any assigned treatment a

Exclusion criteria

Exclusion criteria: Contraindications epinephrine including, hemorrhagic CVA, TIA, and acute MI Heart rate > 100 History of allergy to epinephrine Pregnancy and breastfeeding

Design outcomes

Primary

MeasureTime frame
Clinical symptoms. Timepoint: Before intervention and daily during the study. Method of measurement: Questionnaire.;Oxygen saturation. Timepoint: Before intervention and daily during the study. Method of measurement: Pulse oximeter.;Pulmonary imaging finding. Timepoint: Before intervention and the fifth day of the study. Method of measurement: Computed tomography.

Secondary

MeasureTime frame
Incidence of serious adverse events. Timepoint: Before intervention and daily during the study. Method of measurement: Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParivash Davoodian

Bandare-abbas University of Medical Sciences

parivash.davoodian@hums.ac.ir+98 76 3333 3280

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026