Microneedling plus topical 5-FU in treatment of Vitiligo

Comparison of the Efficacy of Microneedling plus topical 5-FU versus topical Tacrolimus in the Treatment of Vitiligo Patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200506047320N1

Enrollment

Registered

2020-06-30

Start date

2020-03-20

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitiligo. Vitiligo

Interventions

Intervention 1: Intervention group: A group that receives a combination of Microneedling and topical Fluorouracil solution 50 mg/ml every two weeks for 3 months. Intervention 2: Control group: A group

Eligibility

Sex/Gender

All

Age

10 Years to No maximum

Inclusion criteria

Inclusion criteria: All patients with stable vitiligo

Exclusion criteria

Exclusion criteria: Pregnancy and lactation Age under 10 y Lesions on face, genitalia and intertriginous areas Active Koebner phenomenon Coagulopathy Active infection Previous history of keloid or high risk for keloid Drug hypersensitivity

Design outcomes

Primary

Measure	Time frame
Repigmentation level in Vitiligo lesions. Timepoint: At beggining of study and then after treatmen starts every 2 weeks for 3 months. Method of measurement: Based on the percentage of repigmentation and classification as 0 to 25 percent, 25 to 50, 50 to 75 and above 75 percent.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Hatami

Ahvaz University of Medical Sciences

Hatami.mo@mail.ajums.ac.ir+98 71 3636 4577

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026