Cerebral infarction. Cerebral infarction
Conditions
Interventions
Intervention group: All patients (n=9) will be assigned to the single study intervention group. The process of exosome isolation and preparation will be performed in a clinical-grade cleanroom and in
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 80 years Diagnosis of acute ischemic stroke based on clinical and imaging evidence within 24 to 72 h after the onset Baseline National Institutes of Health Stroke Scale (NIHSS) score between 6 and 20
Exclusion criteria
Exclusion criteria: Diagnosis of lacunar or brainstem stroke Acute intracranial hemorrhage History of seizure or current therapy with anti-epileptic medications Any history of traumatic brain injury Any uncontrolled comorbidity, such as diabetes, hepatic, renal, or cardiac failure Ischemic stroke or myocardial infarction within the last 6 months Abnormal renal, hepatic, immunologic, and coagulation profiles Pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety profile of the study intervention. Timepoint: Daily during the first 7 days after the injection and weekly until 3-month after the injection. Method of measurement: Monitoring and evaluating the patients regarding the adverse events. | — |
Secondary
| Measure | Time frame |
|---|---|
| National Institutes of Health Stroke Scale (NIHSS). Timepoint: 1-, 3-, and 6-month after the injection. Method of measurement: Physical examination.;Modified Rankin scale (mRS). Timepoint: 1-, 3-, and 6-month after the injection. Method of measurement: Evaluation of patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRoozbeh Tavanaei
Shahid Beheshti University of Medical Sciences
Outcome results
None listed