Glioma grade 4. Malignant neoplasm of brain
Conditions
Interventions
Intervention group: This group undergoes gene therapy along with standard treatment (chemotherapy and radiotherapy). Then 5×10^5 mesenchymal stem cells infected with lentivirus carrying the Thymidine
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Karnofsky performance status> 70. Adequate hematological function (an absolute neutrophil count > 1500/µl and platelet count > 125000/mm3). Adequate renal function (creatinine < 1.5 times the normal). Adequate hepatic function (aspartate aminotransferase and bilirubin < 1.5 times the normal). Patient who fill informed consent.
Exclusion criteria
Exclusion criteria: Significant vascular disease. History of recurrent thromboembolism. Prior history of hypertensive crisis or hypertensive encephalopathy. Gastrointestinal fistula or perforation. History of intraabdominal or intracranial abscess within 6 months. Serious non healing wound, ulcer and bone fracture.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival (OS) of patients. Timepoint: Before treatment and every three months until the patient's death. Method of measurement: The time from treatment initiation until patient's death.;Radiological progression free survival (PFS) of patients. Timepoint: Before treatment and every three months until the disease recurrence. Method of measurement: The time from treatment initiation until disease progression or worsening. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaeed Oraee Yazdani
Shahid Beheshti University of Medical Sciences
Outcome results
None listed