Intraventricular antibiotic therapy in external ventricular drain-related infection

Efficacy of prophylactic intraventricular administration of vancomycin and gentamicin on external ventricular drain-related infection rate

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200502047277N12

Enrollment

100

Registered

2024-07-07

Start date

2024-07-10

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Presence of cerebrospinal fluid drainage device. Presence of cerebrospinal fluid drainage device

Interventions

Intervention 1: Intervention group 1: Patients in the vancomycin group will receive 20 mg vancomycin in 3 ml of normal saline after withdrawing 4-5 ml of CSF. After that, patients will receive a flush

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 75 years External ventricular drain placement for any indication Written informed consent

Exclusion criteria

Exclusion criteria: Prior hypersensitivity reaction to study drug Active infection

Design outcomes

Primary

Measure	Time frame
The rate of external ventricular drain-related infetion. Timepoint: Over the course of hospitalization. Method of measurement: Obtaining CSF cultures.	—

Secondary

Measure	Time frame
Results of the CSF culture. Timepoint: Over the course of hospitalization. Method of measurement: Obtaining CSF culture.;The duration of using external ventricular drain. Timepoint: Over the course of hospitalization. Method of measurement: Patient follow-up.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeed Oraee Yazdani

Shahid Beheshti University of Medical Sciences

Saeed_o_yazdani@yahoo.com+98 21 25719

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026