Study of Pregabalin effect on breast cancer surgery

Study of Pregabalin Effect on Post Surgical Pain on Breast Cancer Patients Underwent Axillary Dissection: a Double Blind Randomized Clinical Trial Using Placebo

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200502047263N1

Enrollment

250

Registered

2020-05-08

Start date

2019-04-21

Completion date

Unknown

Last updated

2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post op Pain after breast cancer surgery. Malignant neoplasm of breast

Interventions

Intervention 1: Intervention group: 75 mg Pregabalin 1h before surgery orally then every 12h until 15 days after surgery. Intervention 2: Control group: 75 mg Placebo 1h before surgery orally then eve

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients who underwent breast cancer surgery at Shariati hospital and Imam khomeini Cancer institute in 2019

Exclusion criteria

Exclusion criteria: Patient denial to participate in the study Known cases with sensitivity to pregabalin History of seizure Patients who were already using Pregabalin or gabapentin or opioids Patients who were unable to cooperate with data gathering, physically or emotionally GFR less than 60

Design outcomes

Primary

Measure	Time frame
Post op pain score after breast cancer surgery. Timepoint: 24h, 48h, 1w, 1m and 6 month after surgery. Method of measurement: Verbal Numerical Rating Scale (VNRS).	—

Secondary

Measure	Time frame
Morphine usage. Timepoint: after surgery until discharge. Method of measurement: nurse's report.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Masoomzadeh

Tehran University of Medical Sciences

mzmasoomzadeh@yahoo.com+98 31 3668 3368

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026