Patients with repeated implantation failure.
Conditions
Interventions
Intervention 1: Control group: In the control group, on days 9 and 12, normal intrauterine injection of 600µL sterile saline (5 mg / ml) is performed with a fetal transfer catheter. Intervention 2: In
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
No minimum to 40 Years
Inclusion criteria
Inclusion criteria: Age under 40 years (AMH) above one At least twice the previous ART by transferring at least six grade one embryos Healthy uterine cavity in ultrasound and hysteroscopy (lack of uterine anomaly, endometrial polyp, uterine myoma) Absence of endocrinopathy and autoimmune and thrombophilic diseases Normal karyotype Absence of severe male infertility Absence of moderate or severe endometriosis Absence of a specific cause for implantation in previous ARTs Absence of hydrosalpenx
Exclusion criteria
Exclusion criteria: Age over 40 years (AMH) below one Abnormal uterine cavities on ultrasound and hysteroscopy (with uterine anomalies, endometrial polyps, uterine myomas) Endocrinopathy and autoimmune and thrombophilic diseases Abnormal karyotype Severe male infertility Existence of a specific cause of non-implantation in previous ARTs Existence of hydrosalpinx Severe or moderate endometriosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy. Timepoint: According to the random list, patients are divided into intervention and control groups.In both groups, after basic ultrasound on the second day of the cycle, the ART cycle begins, and ovarian stimulation information is recorded for each patient. In patients in the 9 and 12 days of intramuscular injection of dexamethasone 600µL (5mg / ml) with a fetal transfer catheter, the intervention is performed slowly.In patients with the control group, the same normal volume of sterile saline is prescribed.Both groups are followed by transvaginal ultrasound while taking ART.When at least two follicles are seen, 10,000 HCG units are injected and 36 hours later the pancreas is transplanted under vaginal ultrasound. The ultrasound is performed two weeks later and the pregnancy sac is examined. Method of measurement: Pregnancy test(ßHCG). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra sadat Khonsarian
Tehran University of Medical Sciences
Outcome results
None listed