Comparison of intravenous remifentanil and intravenous lidocaine in prevention of cardiovascular response following laryngoscopy and tracheal intubation under genereal anesthesia in limbs surgery.

Comparison of intravenous remifentanil and lidocaine on the cardiovascular response to laryngoscopy and tracheal intubation under general anesthesia in open limbs surgery.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200501047255N1

Enrollment

Registered

2020-07-27

Start date

2020-05-11

Completion date

Unknown

Last updated

2020-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Open reduction and internal fixation of ulna and radius fracture. Condition 2: Open reduction of humerus fracture. Condition 3: Open reduction of tibia fractures. Fracture of shaft of radius Fracture of lower end of humerus Fracture of lower end of tibia

Interventions

Intervention 1: Intervention group: 30of parcipitants that received remifentanil with a dose of 2µg/kg. Intervention 2: Control group: A group of 30 people who received 1.5 micrograms per kilogram of

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Open limbs surgery under general anesthesia Class 1 and 2 of anesthesia risk (According to American society of anesthesiologist's classification),

Exclusion criteria

Exclusion criteria: Difficult intubation prolonged ( more than 30 seconds) attempts at laryngoscopy Repeated attempts at laryngoscopy

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Before induction of anesthesia and just following laryngoscopy and tracheal intubation. Method of measurement: Non-invasive blood pressure measurement with Novin Saadat monitor.;Pulse rate. Timepoint: Before induction of anesthesia and just following laryngoscopy and tracheal intubation. Method of measurement: Non-invasive blood pressure measurement with Novin Saadat monitor.	—

Measure

Time frame

Blood pressure. Timepoint: Before induction of anesthesia and just following laryngoscopy and tracheal intubation. Method of measurement: Non-invasive blood pressure measurement with Novin Saadat monitor.;Pulse rate. Timepoint: Before induction of anesthesia and just following laryngoscopy and tracheal intubation. Method of measurement: Non-invasive blood pressure measurement with Novin Saadat monitor.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Javad nourian

Shahroud University of Medical Sciences

Mtkzf.ms@gmail.com+98 23 3239 5054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026