Heart failure. Heart failure
Conditions
Interventions
Intervention 1: Intervention group: Patients will take one capsule of Astaxanthin daily (containing 20 milligrams of Astaxanthin) made by the company "Zist Fanavary Taravat Zendegi" located at Alzahra
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age 18 years and above known heart failure in stage C, D based on American Heart Association(AHA) criteria and cardiologist diagnosis Willingness to participate in the study and completion of the consent form
Exclusion criteria
Exclusion criteria: Pregnancy and breastfeeding Consumption of alcoholic beverages Drug addiction Suffering from uncontrolled diabetes Use of herbal and medicinal supplements especially antioxidant supplements three months before starting the study Warfarin drug use Following a special diet or exercise program Suffering from chronic liver, kidney and lung diseases Suffering from chronic inflammatory diseases such as Crohn's and ulcerative colitis Suffering from cancer Suffering from acute coronary heart syndrome or heart surgery in the last 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endothelial function (nitric oxide level). Timepoint: The beginning of the study (before the start of the intervention) and 60 days after the start of taking the supplement (the end of the intervention). Method of measurement: Blood test.;Quality of Life. Timepoint: The beginning of the study (before the start of the intervention) and 60 days after the start of taking the supplement (the end of the intervention). Method of measurement: The Minnesota Living with Heart Failure Questionnaire (MLHFQ).;Fatigue severity. Timepoint: The beginning of the study (before the start of the intervention) and 60 days after the start of taking the supplement (the end of the intervention). Method of measurement: Fatigue Severity Scale (FSS).;Severity of shortness of breath. Timepoint: The beginning of the study (before the start of the intervention) and 60 days after the start of taking the supplement (the end of the intervention). Method of measurement: Modified Medical Research Council (MMRC) dyspnea scale.;Appetite score. Timepoint: The beginning of the study (before the start of the intervention) and 60 days after the start of taking the supplement (the end of the intervention). Method of measurement: Simplified Nutritional Appetite Questionnaire (SNAQ).;Oxidative stress indices (malondialdehyde, superoxide dismutase, total antioxidant capacity). Timepoint: The beginning of the study (before the start of the intervention) and 60 days after the start of taking the supplement (the end of the intervention). Method of measurement: Blood test.;Inflammatory markers (C-reactive protein, monocyte chemoattractant protein-1, tumor necrosis factor alpha). Timepoint: The beginning of the study (before the start of the intervention) and 60 days after the start of taking the supplement (the end of the intervention). Method of measurement: Blood test.;Lipid profile. Timepoint: The beginning of the study (before the start of the intervention) and 60 days after the start of taking the supplement | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: The beginning of the study (before the start of the intervention) and 60 days after taking the supplement (the end of the intervention). Method of measurement: Body weight is measured with an approximate of 0.1 kilograms in the morning while fasting, without shoes and with minimal clothing by a digital scale.;Waist circumference. Timepoint: The beginning of the study (before the start of the intervention) and 60 days after taking the supplement (the end of the intervention). Method of measurement: Waist circumference is also measured with an approximate of 0.1 centimeters from the area of the smallest diameter between the last rib or the lower edge of the chest and the crest of the frontal superior iliac spine with a non-stretchable tape measure while the person is standing, measured and recorded.;Body Mass Index (BMI). Timepoint: The beginning of the study (before the start of the intervention) and 60 days after taking the supplement (the end of the intervention). Method of measurement: BMI is calculated by dividing weight (kilograms) by the square of height (meters). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarzieh Kafeshani
Esfahan University of Medical Sciences
Outcome results
None listed