Rheumatoid arthritis. Rheumatoid arthritis
Conditions
Interventions
Intervention 1: Intervention group: Astaxanthin is a natural carotenoid from the xanthophyll group, which exists in different amounts in different marine organisms such as algae, shrimp, crab, yeast,
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 65 years Rheumatoid arthritis diagnosis by a specialist physician based on criteria (ACR) Having a disease activity score (DAS) higher than 3.2 Willingness to participate in the study and complete the consent form before starting the supplement therapy Not taking herbal and medicinal supplements, especially antioxidant supplements, in the three months before the start of the study Having a body mass index of 18.5 to 40
Exclusion criteria
Exclusion criteria: Pregnancy and breastfeeding Smoking and being exposed to cigarette smoke on a daily basis Consumption of alcoholic beverages Following a special diet or exercise program Suffering from diseases such as diabetes mellitus, high blood pressure, thyroid disorder, kidney failure, liver dysfunction, Cushing's syndrome Inflammatory bowel diseases (Crohn's and ulcerative colitis) Using traditional medicine methods in the last 3 months Infectious rheumatoid arthritis Having a history of bariatric surgery Consumption of less than 80% of the total astaxanthin food supplement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antioxidant status. Timepoint: The patient's antioxidant status will be measured at the beginning of the study (before the start of the intervention) and 60 days after the start of the supplement (the end of the intervention). Method of measurement: Blood tests.;Inflammation status. Timepoint: The measurement of inflammation will be done at the beginning of the study (before the intervention) and 60 days after the start of the supplement (the end of the intervention). Method of measurement: blood tests.;Physical performance score. Timepoint: Physical performance will be measured at the beginning of the study (before the start of the intervention) and 60 days after the start of the supplement (the end of the intervention). Method of measurement: Disease activity score-28 will be used to measure the physical performance score.;Illness severity. Timepoint: The severity of the disease will be measured at the beginning of the study (before the start of the intervention) and 60 days after the start of the supplement (the end of the intervention). Method of measurement: Visual Analogue Scale (VAS) will be used to measure the illness severity.;Health evaluation. Timepoint: The patient's health will be evaluated at the beginning of the study (before the start of the intervention) and 60 days after the start of the supplement (the end of the intervention). Method of measurement: Health Assessment Questionnaire (HAQ) will be used to assess the patient's health. | — |
Secondary
| Measure | Time frame |
|---|---|
| Grip strength. Timepoint: Muscle strength will be measured at the beginning of the study (before the start of the intervention) and 60 days after the start of the supplement (the end of the intervention). Method of measurement: Hand grip will be used to measure grip strength.;C reactive protein (CRP). Timepoint: The serum level of C-reactive protein will be measured at the beginning of the study (before the start of the intervention) and 60 days after the start of the supplement (the end of the intervention). Method of measurement: Blood test.;Red blood cell sedimentation rate. Timepoint: Red blood cell sedimentation rate will be measured at the beginning of the study (before the start of the intervention) and 60 days after the start of the supplement (the end of the intervention). Method of measurement: Blood test.;Interleukin 6 serum level. Timepoint: Interleukin-6 serum levels will be measured at the beginning of the study (before the intervention) and 60 days after the start of the supplement (the end of the intervention). Method of measurement: Blood test.;Malondialdehyde serum level. Timepoint: The measurement of serum malondialdehyde level will be done at the beginning of the study (before the start of the intervention) and 60 days after the start of taking the supplement (the end of the intervention). Method of measurement: Blood test.;Total antioxidant capacity (TAC). Timepoint: Total antioxidant capacity will be measured at the beginning of the study (before the start of the intervention) and 60 days after the start of the supplement (the end of the intervention). Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarzieh Kafeshani
Esfahan University of Medical Sciences
Outcome results
None listed