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Effect of Thalidomide in Covid 19 pneumonia

Effectiveness and safety of thalidomide in moderate COVID-19 pneumonia: A randomized clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200428047232N1
Enrollment
60
Registered
2020-07-05
Start date
2020-05-09
Completion date
Unknown
Last updated
2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pneumonia caused by Coronavirus 2019, COVID19. Coronavirus infection, unspecified

Interventions

Intervention 1: Intervention group: Patients in this group are treated with 100 mg oral thalidomide tablets manufactured by Ibn Sina Company on a daily basis for up to fourteen days. These drugs are a

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 18-75 year old men and 50-75 year old women admitted in hospital Percentage of oxygen saturation at the time of admission: 89-85% (provided it is modified with Nazal auxiliary oxygen to more or equal to 90%) or oxygen saturation percentage of 90-93% and the number of breaths per minute more or equal to 30 Clinical manifestations associated with COVID-19 pneumonia with positive PCR test or HR-CT scan

Exclusion criteria

Exclusion criteria: Previous Chronic lung disease Multi-organ failure at admission

Design outcomes

Primary

MeasureTime frame
Time to reach clinical recovery. Timepoint: Daily visit in the hospital every 8 hours by the physician. Method of measurement: Pulse oximetery device.

Secondary

MeasureTime frame
28 days survival rate. Timepoint: Weekly up to 4 weeks from the time of hospitalization to 4 weeks after discharge. Method of measurement: Telephone call.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamane Pourajam

Esfahan University of Medical Sciences

Spourajam@gmail.com+98 31 3337 7986

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026