Patients with breast cancer who are taking herceptin.
Conditions
Interventions
Intervention group: Patients with breast cancer who take herceptin and take syrup with it.
Sponsors
Zanjan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
38 Years to No maximum
Inclusion criteria
Inclusion criteria: Breast cancer in the early stages of the disease HER2 positive Women over 18 years Lack of underlying heart problems The desire to participate in the study
Exclusion criteria
Exclusion criteria: Suffering from other cancers Thyroid disorders Kidney disorders Getting other vitamin or mineral supplements Patients with lower body mass index18/5 Lack of desire to continue participating in the project
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Determining the effect of quince syrup on cardiac function-related factors (left ventricular emptying fraction) in patients with breast cancer receiving fruit syrup by comparison with patients with breast cancer receiving placebo. 2- Determining the effect of quince syrup on the findings of ECG in patients with breast cancer receiving the syrup compared to patients receiving placebo.3. Determining the effect of quince syrup on the plasma levels of troponin I in patients with breast cancer receiving fruit syrup who have evidence of cardiomyopathy by comparing them with patients with breast cancer receiving placebo who have evidence of cardiomyopathy.4. Determining the effect of quince syrup on creatinine plasma plasma levels in patients with breast cancer receiving fruit syrup by comparing with patients with breast cancer receiving placebo. Timepoint: Patients will drink the syrup daily with some water for three months. The placebo will appear in the same bottles as the intervention group. The syrup bottles and placebo are given to patients on a monthly basis, and the researcher will follow up on the consumption or report possible side effects on the phone and on a weekly basis. Method of measurement: Blood sampling to check the blood levels of biomarkers related to cardiac poisoning caused by prescribing herceptin in this disease will be done at the beginning and end of the study, ie 3 months later. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1- Receiving fruit syrup has an effect on heart function factors (left ventricular emptying fraction) in patients with breast cancer. 2- Receiving fruit syrup has an effect on the findings of ECG in patients with breast cancer. Fruit syrup affects the amount of troponin I in patients with breast cancer who have had cardiomyopathy. 4. Fruit syrup intake affects the amount of creatine kinase in patients with breast cancer. Timepoint: At the beginning of the study (before the start of the intervention) and 3 months after the start of the syrup. Method of measurement: Ventricular drainage fraction by echocardiography and troponin I by immunoenzymatic fluorescent assay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Reza
Zanjan University of Medical Sciences
Outcome results
None listed