Pain control in bone marrow aspiration and biopsy

Determining and comparing the effectiveness of intravenous injection of apotel, promethazine syrup and local anesthesia with intravenous injection of pethidine and local anesthesia in controlling pain in patients candidate for bone marrow aspiration and biopsy.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200427047215N2

Enrollment

Registered

2021-01-16

Start date

2021-01-19

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone marrow disease. Multiple myeloma and malignant plasma cell neoplasms

Interventions

Intervention 1: Intervention group: 1. Infusion of one gram ampoule in 100 cc of normal saline serum half an hour before the procedure 2. 5 cc of promethazine syrup (25 mg) 30 minutes before the pr

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Age 18-55 years Conscious consent to enter the study BMI 18-25

Exclusion criteria

Exclusion criteria: Mental retardation Generalized anxiety disorder Major Depressive Disorder Pregnancy Lactation Drug addiction Take analgesic less than 4 hours before admission Hypersensitivity to apotel, promethazine and lidocaine GFR < 30 Cirrhosis Child B & C

Design outcomes

Primary

Measure	Time frame
Reduction of pain during bone marrow biopsy and aspiration. Timepoint: Immediately after completing the procedure and 30 minutes later in the intervention and control groups. Method of measurement: To estimate the severity of pain and the effect of the drug in relieving the patient's pain from the quantitative scale VAS(Visual Analog Scale) is used.;Anxiety after completing the procedure. Timepoint: After the procedure and 30 minutes later, the patient's anxiety is rated from 1 to 10, depending on the severity. Method of measurement: Anxiety severity is divided from zero to ten using a questionnaire.	—

Measure

Time frame

Reduction of pain during bone marrow biopsy and aspiration. Timepoint: Immediately after completing the procedure and 30 minutes later in the intervention and control groups. Method of measurement: To estimate the severity of pain and the effect of the drug in relieving the patient's pain from the quantitative scale VAS(Visual Analog Scale) is used.;Anxiety after completing the procedure. Timepoint: After the procedure and 30 minutes later, the patient's anxiety is rated from 1 to 10, depending on the severity. Method of measurement: Anxiety severity is divided from zero to ten using a questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Darakhshandeh

Esfahan University of Medical Sciences

alidarakhshandeh@med.mui.ac.ir+98 31 3777 2640

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026