Pneumonia induced by covid19. COVID-19, virus identified
Conditions
Interventions
Intervention 1: Intervention group:??Slow release Indomethacin tablets, 75 mg daily for five days. Made by Aria Pharmaceutical Company. Intervention 2: Control group: A placebo similar to indomethacin
Sponsors
Isfahan University of Medical Sciences Vice Chancellor for Research and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients 18 to 75 years old hospitalized Patient with SpO2:85-89% on room air at admission (if correct with nasal O2 maximum 6 liter/min to SpO2>=90 ) Patients with SpO2: 90-93% and RR>=30 clinical compatible patients with positive RT-PCR test or consistent HRCT to covid19 pneumonia Sign the study participation form
Exclusion criteria
Exclusion criteria: Known hypersensitivity to indomethacin or any components of NSAIDs History of asthma, urticarial, or other allergic type reaction after taking aspirin or NSAIDs GFR less than 60ml/minute/1.7m2 Patients with active gastrointestinal bleeding The need for intubation in the first 24 hours of hospitalization Patients with multi organ failure Patients with shock state at admission Pregnant woman Lactating woman Patients with active peptic ulcer Consumption of NSAID on admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to clinical recovery. Timepoint: Control clinical signs daily until discharge from the hospital. Method of measurement: Fever control with thermometer, oxygen saturation control with pulsoximetry.;14 days readmission after discharge. Timepoint: Up to 14 days after discharge. Method of measurement: All patients will be given a contact number to notify them if they are hospitalized again. All patients will be monitored by phone weekly for up to 4 weeks after the first day they are admitted.;Time to intubation. Timepoint: Control of oxygen saturation, respiratory status every 6 hours during hospitalization. Method of measurement: If the patient needs intubation due to reduced oxygen saturation or increased respiration rate, the date of incubation will be recorded on a daily basis from the time of hospitalization. | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival 28 days after hospitalization. Timepoint: From the first day of hospitalization to 28 days after hospitalization. Method of measurement: A questionnaire is used to measure survival. At the time of hospitalization, this questionnaire is completed daily by one of the researchers. After discharge, the patient's condition will be monitored weekly for up to 4 weeks after the first day of hospitalization. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Darakhshandeh
Esfahan University of Medical Sciences
Outcome results
None listed