COVID-19 disease. COVID-19
Conditions
Interventions
Intervention 1: Intervention group: Patients receive low-dose cyclosporine for at least 7 days orally.Also, the routine treatments (The last national protocol for COVID-19 treatment) will be given to
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Positive PCR test Age between 18-60 years patient with acute respiratory infectious symptoms and lung involvement non-intubated patients
Exclusion criteria
Exclusion criteria: Allergy to Cyclosporin Not willing to participate Patients with cancer Under treatment with immunosuppressor drugs Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change oxygenation. Timepoint: Daily for two weeks. Method of measurement: pulse oximeter.;Creatinine clearance status. Timepoint: Days 2, 4 and 6. Method of measurement: laboratory exam.;Inflammatory factors. Timepoint: Days 1 and 7. Method of measurement: Flow Cytometry.;Number of days hospitalized in the ward. Timepoint: Seventh day onward. Method of measurement: day.;Serum D.dimer. Timepoint: Days 1,3 and 7. Method of measurement: Enzymes.;Serum ferritin level. Timepoint: Days 1,3 and 7. Method of measurement: laboratory test.;TCD4+, TCD8+, B Cell. Timepoint: Days 1 and 7. Method of measurement: Flow Cytometry.;CRP. Timepoint: Days 1 and 7. Method of measurement: mg/L. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSalman Khazaei
Hamedan University of Medical Sciences
Outcome results
None listed