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Safety and efficacy of cervical administration of misoprostol in induction of labor compared to vaginal and sublingual administration

Safety and efficacy of cervical administration of misoprostol in induction of labor in mothers with unripe cervix and term pregnancy compared to vaginal and sublingual administration: a randomized clinical trial.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200421047152N4
Enrollment
123
Registered
2023-10-11
Start date
2023-10-17
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Labour induction. Failed induction of labour

Interventions

Intervention 1: Intervention group with intracervical misoprostol: In this group, 25 micrograms of intracervical misoprostol is prescribed to induce labor. If appropriate contractions are not reached,

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Women aged 18-40 years Singleton pregnancy Cephalic presentation Gestational age more than 37 weeks Appropriate pelvic examination Intact membranes Fetal weight between 90-10th percentile estimated by ultrasound ishop score less than or equal to 6

Exclusion criteria

Exclusion criteria: Birth history equal to or more than 3 Blood pressure equal to or greater than 140/90 mmHg Proteinuria or preeclampsia Getational diabetes Unreliability of fetal heart trace or any fetal distress Polyhydramnios or oligohydramnios The possibility of fetal macrosomia Intrauterine fetal death Previous history of uterine surgery Bleeding Placenta previa

Design outcomes

Primary

MeasureTime frame
Time to reach active labour phase. Timepoint: Immediately after intervention. Method of measurement: Physical examination.

Secondary

MeasureTime frame
Time to delivery. Timepoint: Between intervention and delivery. Method of measurement: Clinical examination.;Percentage of cesarean section. Timepoint: 24 hours after intervention. Method of measurement: Clinical assessment.;Neonatal apgar. Timepoint: First and fifth minutes after delivery. Method of measurement: clinical assessment.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNooshin Eshraghi

Iran University of Medical Sciences

eshraghi.n@iums.ac.ir+98 21 5560 6034

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026