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Effect of endometrial Scratching on pregnancy outcome after intrauterine insemination

Effect of endometrial Scratching on pregnancy outcome after intrauterine insemination (IUI) in patients with previous IUI failure, a randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200421047152N2
Enrollment
192
Registered
2023-01-30
Start date
2023-01-20
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility needs intrauterine insemination (IUI). Artificial insemination

Interventions

Intervention 1: Endometrial scratching intervention group: Endometrial scratching is done in the intrauterine sperm injection (IUI) cycle on day 5 or 6 from the beginning of the menstrual cycle. To pe

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 42 Years

Inclusion criteria

Inclusion criteria: Age 20-42 year Unexplained infertility or mild male factor infertility Failure of at least two previous intrauterine insemination (IUI) cycles

Exclusion criteria

Exclusion criteria: Presence of endometriosis in stage 3 and 4 diagnosed by ultrasound Sever male factor infertility Underlying metabolic disease (hyperprolactinemia, thyroid disorder or any known metabolic disease) Ovarian follicle-stimulating hormone (FSH) level > 12 Body mass measurement > 30

Design outcomes

Primary

MeasureTime frame
Clinical pregnancy rate. Timepoint: 5-6 weeks after IUI. Method of measurement: Transvaginal sonography.

Secondary

MeasureTime frame
Live birth rate. Timepoint: 28 weeks of pregnancy. Method of measurement: Phone based interview.;Chemical pregnancy rate. Timepoint: 14 days after IUI. Method of measurement: Measurement of beta human chorionic gonadotropin serum level (Beta HCG).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehnaz Mohabatian

Iran University of Medical Sciences

dr.mohabatian@gmail.com+98 21 86709

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026