locally advanced rectal cancer. Malignant neoplasm of rectum
Conditions
Interventions
Intervention group: newly diagnosis locally advanced rectal cancer in included.they recived Induction chemotherapy with 2 course of CAPOX regimen every 3 weeksthen ChRt with CAPOX and then surgery aft
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: rectal cancer lower than 15 cm anal verge T3 or T4 or N+ 2 = performance status GFR = 50 liver function test upper limit normal bilirubin lower than 3rd upper limit normal more than 18 years , less thean 65 years
Exclusion criteria
Exclusion criteria: pathology except adenocarcinoma T1,2 ,N0 metastatic disease history of malignancy history of chemotherapy or radiation therapy pregnancy and breast feeding recurrent rectal cancer medical disease forrbidden chemotherapy or radiation therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathologic complete response. Timepoint: after surgery. Method of measurement: pathologic evaluation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Grade 3 or more of acute toxicity. Timepoint: during chemotherapy and chemoradiation. Method of measurement: observation symptoms and lab test.;R0 Resection. Timepoint: after surgery. Method of measurement: pathology.;Sphincter pereservation. Timepoint: after surgery. Method of measurement: type of surgery. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBehnaz Behzadi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed