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The effect of Ziziphus jujube in the treatment of anxiety and depression

Comparison of effect between Ziziphus jujube fruit and benzodiazepines in patients with depression and anxiety disorders treated with selective serotonin reuptake inhibitors

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200418047116N4
Enrollment
50
Registered
2023-10-09
Start date
2023-11-22
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: anxiety. Condition 2: depression. Anxiety disorder, unspecified Major depressive disorder, single episode, unspecified

Interventions

Intervention 1: Intervention group: Intervention group: Jujube powder purchased from Shayna, a 15 gram sachet once a day, will be added to the main treatment (SSRI) for one month. Intervention 2: Cont

Sponsors

Gonabad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Referees to the specialized psychiatric clinic of Bohlool Hospital in Gonabad city who have been diagnosed with anxiety and depression disorders based on DSM-V criteria. Candidate patients for treatment with SSRI and benzodiazepines, Having written informed consent to participate in the study Age 18 to 65 years

Exclusion criteria

Exclusion criteria: History of sensitivity to jujube fruit consumption (based on the individual's own report) History of addiction Pregnancy or intention to become pregnant History of other psychiatric disorders Breastfeeding Taking jujube or other herbal medicines during the last 4 weeks before the start of the study Contraindications for benzodiazepine or SSRI administration Mental retardation Taking drugs that interfere with study drugs

Design outcomes

Primary

MeasureTime frame
Anxiety scores in the Beck questionnaire. Timepoint: Before the intervention, one month and three months after the intervention. Method of measurement: Beck anxiety questionnaire.

Secondary

MeasureTime frame
Severity of Illness. Timepoint: One month and three months after the intervention. Method of measurement: Global Clinical Perception Questionnaire - Severity of Illness.;Drowsiness check. Timepoint: One month and three months after the intervention. Method of measurement: Complications survey questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNegar Shafaei Bajestani

Gonabad University of Medical Sciences

negar.shafaei89@gmail.com+98 51 5723 6833

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026