Pneumonia induced with COVID-19. COVID-19 pneumonia , virus identified
Conditions
Interventions
Intervention 1: Intervention group: The patients will receive the cocktail contains 100 mg of Thiamine (Ampoule B complex, Darou Pakhsh Co.), 6 g Ascorbic acid (ampoule of vitamin C, Darou Pakhsh Co
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Informed written consent is obtained before the start of the study process. patient understands and agrees with planned study methods. Agree on sampling the oropharyngeal polymerase chain reaction and venous blood samples according to the protocol. A non-pregnant woman and man is 18 years of age or older when entering the program. Positive Covid 19 polymerase chain reaction test with at least one of the following: radio-graphic changes or with clinical signs requiring mechanical ventilation and air oxygen saturation level less than or equal to 94% in room air. Women of childbearing age should have at least one contraceptive method during the study
Exclusion criteria
Exclusion criteria: Allergic reaction to Hydrocortisone, Ascorbic acid or thiamine Hospitalization less than 72 hours Active kidney stone The patient participates in another clinical trial at the same time
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of improvement in the ratio of incoming oxygen flow to arterial oxygen pressure (SF ratio) compared to baseline. Timepoint: at baseline and daily. Method of measurement: Measurement of SPO2/FIO2 with pulse oximetery.;Time to mechanical ventilation weaning. Timepoint: Daily. Method of measurement: Counting the days of using ventilator.;Change in the Murray Lung Injury Score from baseline to 72 h. Timepoint: Baseline and daily to 72 h. Method of measurement: Murray Lung Injury Score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in the Sequential Organ Failure Assessment (SOFA) score from baseline to 72 h. Timepoint: Baseline and daily to 72 h. Method of measurement: Measurement of SOFA score.;Change in National Early Warning Score (NEWS) from baseline to discharge. Timepoint: Baseline and daily. Method of measurement: Measurement of NEWS score. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRasol Aliannejad
Tehran University of Medical Sciences
Outcome results
None listed