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Comparative effect of chlorhexidine mouthwash with plant-based mouthwash in the prevention of pneumonia

A comparative study of chlorhexidine mouthwash with plant-based mouthwash in the prevention of ventilator-related pneumonia in patients admitted to the intensive care unit

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200413047059N1
Enrollment
80
Registered
2020-11-09
Start date
2018-07-23
Completion date
Unknown
Last updated
2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilate-related pneumonia. Ventilator associated pneumonia

Interventions

Intervention 1: Intervention group: First, treatment with chlorhexidine is 0.2%. The frequency, timing, and manner of mouth washing in this group will be performed in the same way, three times a day f

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 18 years Requires mechanical ventilation for at least 48 hours Do not use the chip pipe before entering the intensive care unit No specific lesions in and around the mouth Lack of safety defects Do not take antibiotics before hospitalization No pregnancy Lack of allergy to plant compounds Has natural teeth Free and informed written consent of the patient's companion or guardian to participate in the study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Ventilator-related pneumonia. Timepoint: At the beginning of the study and 3 weeks after using two mouthwashes. Method of measurement: A microbial infection of the lung that occurs more than 48 hours after mechanical ventilation with a ventilator. Diagnosis of this type of pneumonia is based on the symptoms of pulmonary infection (including: purulent discharge, fever and leukocytosis), bacteriological evidence of pulmonary infection, and evidence of lung infection on specific radiographic images.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactYeganeh Fatemi

Esfahan University of Medical Sciences

ygn.ftm1994@gmail.com+98 31 5550 0111

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026