benign prostate hyperplasia. Enlarged prostate without lower urinary tract symptoms
Conditions
Interventions
Intervention 1: Intervention group: 3 capsules contain 250 mg of pomegranate peel extract, prepared in pharmaceutics laboratory of pharmacy school, daily for 4 month. Intervention 2: Control group:3 p
Sponsors
Mashhad University of Medical Sciences
Rezvan Danesh Danial company
Eligibility
Sex/Gender
Male
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: age between 50-80 years Mild to moderate clinical diagnisis of BPH (patient has lower urinary (based on international prostate symptom score (IPSS)<18)
Exclusion criteria
Exclusion criteria: simultaneous use of BPH medications except tamsulosin use of supplements which existing in BPH such as saw palmetto , vitamin E and Quercetin vitamins having prostate or bladder cancer history of prostate surgery PSA>4mg/ml Post void residue (PVR)=200 ml history of allergy to pomegranate and its derivatives use of medications with considerable metabolism through Cytochrome 3A4
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PSA serum level. Timepoint: at the beginning of the study and after 4m. Method of measurement: laboratory measurement.;Prostate size and post void volume. Timepoint: at the beginning of the study and after 4m. Method of measurement: sonography.;Clinical assessment. Timepoint: at the beginning of the study and after 2 and 4m. Method of measurement: review and physical examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse drug reaction assessment e.g. low blood pressure. Timepoint: at the beginning of the study and monthly. Method of measurement: review and physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyyed Hossein Hasheminezhad
Mashhad University of Medical Sciences
Outcome results
None listed