Cancer.
Conditions
Interventions
Intervention 1: Intervention group:in the intervention group, two 40mg synacorcumin capsules per day, made by Elixir Nano Sinat, are prescribed for six chemotherapy courses, and in the control group,
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients with cancer and candidates for chemotherapy with regimen containing cisplatin at a dose of 70mg/m2 every three weeks or 40mg/m2 weekly Patient age above 18 years and below 70 years GFR>60 ml/min At the start of chemotherapyNormal liver function Normality of patients' CBC
Exclusion criteria
Exclusion criteria: Allergy to curcuminPatient dissatisfactionReduction of patient's GFR below 45ml/min during treatmentReceiving other nephrotoxic drugs such as aminoglycosides, amphotericin, vancomycin Patients with chronic heart failure EF<60%Patients with untreated hypothyroidism or hyperthyroidismPatients with active infectionReceiving anti-inflammatory and antioxidant drugs at the same timeUnfavorable health status (PS<70%) based on karnofsky index
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum ceratinine level, BUN. Timepoint: ?At the beginning of each chemotherapy course. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSare Hosseini
Mashhad University of Medical Sciences
Outcome results
None listed