COVID-19 Disease. Coronavirus infection, unspecified site
Conditions
Interventions
In 30 patients with respiratory failure and ARDS caused by COVID-19 undergoing mechanical ventilation or oxygen therapy, antivirals and supportive care therapies will be continued, and 200-400 cc of
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age over 18 years Confirmed COVID-19 clinically and positive PCR Severe bilateral pulmonary involvement on CT scan or chest x-ray Pao2/Fio2<300 Need for oxygen therapy or mechanical ventilation
Exclusion criteria
Exclusion criteria: Blood group incompatibility Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of convalescent plasma. Timepoint: Blood and plasma will be taken from patients who have been symptom free for 14-17 days. If it is less than 14 days, the donor should have 2 negative tests in two different days. Method of measurement: ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxygenation. Timepoint: Daily until discharge or death. Method of measurement: ABG.;SOFA score. Timepoint: Daily until discharge or death. Method of measurement: Questionnaire.;Duration of mechanical ventilation. Timepoint: until discharge or death. Method of measurement: Questionnaire.;Duration of admission. Timepoint: Daily until discharge or death. Method of measurement: Questionnaire.;Mortality. Timepoint: Admission period. Method of measurement: patient's file. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHaleh Mikaeili
Tabriz University of Medical Sciences
Outcome results
None listed