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The effect of elderberry syrup against COVID-19 symptoms

A comparison of Elderberry (Sambucus nigra) extract syrup and placebo against COVID-19 symptoms in outpatients and home quarantined patients: A randomized double-blind clinical trial

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200406046965N1
Enrollment
40
Registered
2020-04-12
Start date
2020-04-20
Completion date
Unknown
Last updated
2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 disease. COVID-19, virus identified

Interventions

Intervention 1: Intervention group:The patients will receive 10 ml of elderberry extract syrup 3 times daily (2.6 g of elderberry extract per day equivalent to 15.76 g of fresh elderberries) beside th

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: A definitive diagnosis of COVID-19 infection based on laboratory confirmation (lymphocytopenia, increased quantitative CRP, chest X-ray results) and clinical symptoms of patients including fever, coughs and myalgia Outpatients and home quarantined patients

Exclusion criteria

Exclusion criteria: Hospitalization Age> 65 y and <18 y Patients with catheter Patients receiving chemotherapy drugs, corticosteroids and theophylline Autoimmunity Gastrointestinal diseases Migraine Diabetes Hypokalemia Myalgia Respiratory diseases Smoking Pregnancy and breast feeding

Design outcomes

Primary

MeasureTime frame
Fever. Timepoint: Days 3, 7 and 14 after the intervention beginning. Method of measurement: Thermometer.;Shortness of breath. Timepoint: Days 3, 7 and 14 after the intervention beginning. Method of measurement: Autosaturation device, Counting the number of breaths in 1 minute.;Coughs. Timepoint: Days 3, 7 and 14 after the intervention beginning. Method of measurement: Patient follow up.;Myalgia. Timepoint: Days 3, 7 and 14 after the intervention beginning. Method of measurement: Patient follow up.

Secondary

MeasureTime frame
Lymphocytopenia. Timepoint: days 3, 7 and 14 after the intervention beginning. Method of measurement: Cell counter.;C-reactive protein. Timepoint: days 3, 7 and 14 after the intervention beginning. Method of measurement: CRP kit.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Ahmad Emami

Mashhad University of Medical Sciences

emamia@mums.ac.ir+98 51 3180 1267

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026