COVID-19 Disease. COVID-19
Conditions
Sponsors
Artesh University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patient with moderate to severe Covid-19 admitted to ICU PaO2/FiO2 Less than 300 Progression of disease severity and not responding to standard treatment prediction of intubation for next 24 hours
Exclusion criteria
Exclusion criteria: Uncontrolled diabetes mellitus Active GI bleeding history of corticosteroid hypersensitivity sever electrolyte imbalances Procalcitonin more than 0.5 active bacterial, viral ( HIV, Hepatitis) and fungal infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality rate. Timepoint: from including to study to 60 days. Method of measurement: observation.;Blood O2 saturation. Timepoint: before and during the study for 14 days. Method of measurement: pulse Oximeter.;Oxygen therapy need. Timepoint: before and during the study for 14 days. Method of measurement: Clinical. | — |
Secondary
| Measure | Time frame |
|---|---|
| Chest CT Scan changes 48 hours after starting pulse therapy. Timepoint: 48 hours after starting methylprednisolon pulse therapy. Method of measurement: Chest CT Scan.;ICU length of stay. Timepoint: During the study until ICU discharge. Method of measurement: Patients file.;Sequential Organ Failure Assessment (SOFA) Score changes. Timepoint: before and during the study. Method of measurement: clinical. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactEbrahim Hazrati
Artesh University of Medical Sciences
Outcome results
None listed