Autistic Disorder. Autistic disorder
Conditions
Interventions
Intervention 1: Intervention group: Oxytocin nasal spray, including oxytocin peptide, 25 ml bottle, 2 times a day, two puffs in each nostril, including 48 international units of oxytocin daily, for 8
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 56 Years
Inclusion criteria
Inclusion criteria: Age between 16 years and zero months to 55 years and 11 months Confirmation of diagnosis by a psychiatrist based on dsm5 Complete physical examination and normal laboratory tests Ability to understand and speak Persian fluently Ability to read and understand the consent form in full and if it is not possible for the legal guardian to read and sign the form Clinical global impression-severity CGI-S score above 4 in screening Intelligence score in Stanford test - above 75
Exclusion criteria
Exclusion criteria: Patients with nasal septal deformity and previous epithelial injuries and a history of nasal surgeries with a risk of nasal epithelium damage and people with a history of inhaled substance use Patients with nasal congestion due to colds Patients in the acute phase of psychiatric illness or with thoughts of death and suicide Having a history of neurological diseases, seizures and head injuries People with a history of neurological or metabolic disease that affects their sensory and motor function, etc. Receive stimulant medications History of uncontrolled cardiovascular, renal and hepatic diseases Pregnant women or young women who do not take oral contraceptives People whose type and dose of psychiatric medication have changed in the last 4 weeks People with a history of chronic oxytocin treatment History of allergy to oxytocin and syntocinin and all its compounds asthma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improving the social symptoms of adults with autism. Timepoint: Start of study, 4 weeks later, 8 weeks later. Method of measurement: Social responsiveness scale -social motivation subscale (SRS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaba Faraji Niri
Tehran University of Medical Sciences
Outcome results
None listed