Condition 1: COVID-19. Condition 2: COVID-19. virus identified virus not identified
Conditions
Interventions
Intervention 1: Intervention group: Tofacitinib10 mg (Rofanib, Nano Alvand ) 1 oral tablet daily + Remdesivir IV 100 mg daily for 14 days or hospital discharge (whichever comes first). Intervention 2
Sponsors
Rasht University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: All patients with severe Covid-19 admitted to the ICU of Razi Hospital in Rasht for period of March- June 2021 Age greater than or equal to 18 years Patients admitted with the following criteria: fever (oral temperature greater than 37.2 ° C), dry cough, severe tiredness or dyspnea At least one of the following criteria : positive PCR OR lung involvement on chest X-ray / CT scan Absolute lymphocyte count greater than or equal to 200 per cubic millimeter Absolute neutrophil count greater than or equal to 1000 per milliliter Cubic meters Hemoglobin above 8 grams per deciliter
Exclusion criteria
Exclusion criteria: Lack of informed consent Lack of patient cooperation Having pulmonary embolism or intravascular thrombosis Having another active infection Having diverticulitis and gastric ulcer Having tuberculosis or hepatitis B or active hepatitis C or HIV Any major drug interaction between routine patient's drugs with any of the study drugs Pregnancy and lactation Simultaneous presence in other research study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time required to improve clinical symptoms and within 14 days of treatment start. Timepoint: Daily from the first day of intervention. Method of measurement: Physical examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Body temperature. Timepoint: Daily from the first day of intervention. Method of measurement: Thermometer.;Heart rate. Timepoint: Daily from the first day of intervention. Method of measurement: Pulse oxymeter.;Pulmonary radiological state. Timepoint: Weekly. Method of measurement: CT scan.;Blood pressure. Timepoint: Daily from the first day of intervention. Method of measurement: Barometer.;Mechanical ventilation. Timepoint: Daily from the first day of intervention. Method of measurement: Physical examination.;Duration of hospitalization in the intensive care unit. Timepoint: Daily from the first day of intervention. Method of measurement: Record in the patient file.;Mortality. Timepoint: Daily from the first day of intervention. Method of measurement: Record in the patient file.;Respiration rate. Timepoint: Daily from the first day of intervention. Method of measurement: Count.;Intubation. Timepoint: Daily from the first day of intervention. Method of measurement: Physical examination.;SPO2. Timepoint: Daily from the first day of intervention. Method of measurement: Pulse-oxy meter.;D-Dimer. Timepoint: Every 3 days from the first day of intervention. Method of measurement: Fluorescence immunochromatography.;Creatine phosphokinase. Timepoint: Every 3 days from the first day of intervention. Method of measurement: International Federation of Clinical Chemistry (IFCC).;C reactive protein. Timepoint: Every 3 days from the first day of intervention. Method of measurement: Turbidometry.;Erythrocyte sedimentation rate. Timepoint: Every 3 days from the first day of intervention. Method of measurement: Westergren method.;Ferritin. Timepoint: Every 3 days from the first day of intervention. Method of measurement: Chemiluminescence method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNematollah Ahangar
Rasht University of Medical Sciences
Outcome results
None listed