Atrial Fibrillation. Unspecified atrial fibrillation
Conditions
Interventions
Intervention 1: Intervention group: Patients in the intervention group will be given orally 1 mg of colchicine every 12 hours 24 hours before surgery, then 0.5 mg daily if they weigh less than 70 kg o
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patient between 18_80 years old Patient with CAD and candidate for CABG
Exclusion criteria
Exclusion criteria: Preoperative AF Patients with pacemakers Patient with Clcr<30ml/min Severe hepatic insufficiency or transaminase level more than 3 times higher than normal Breastfeeding or pregnancy Colchicine intolerance or allergy Lack of patients consent to participate in study Presences of sick Sinus syndrom Previous cardiac rhythm disorder,conduction blocks of any degree Co administration with strong pgp and 3A4 inhibitors (voiconazol,ketoconazole,fluconazole,itraconazole,clarithromycin,etc.) Taking anti arrhythmic medicines except beta blockers during past months of surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Atrial fibrilation. Timepoint: Monitoring up to 14 days. Method of measurement: ECG. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of hospitalization. Timepoint: From CABG surgery to hospital discharge. Method of measurement: Monitoring.;Inflammatory factors (CRP,IL6). Timepoint: Day 1 and day 7. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamideh Abbaspour Kasgari
Mazandaran University of Medical Sciences
Outcome results
None listed