nephrotoxicity. Nephropathy induced by other drugs, medicaments and biological substances
Conditions
Interventions
Intervention 1: In the intervention group, patients will be given N-Acetylcysteine (NAC) at a dose of 2 gr intravenously once a day for 5 days along with colistin with a loading dose of 300 mg colisti
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients over 18 years old Use of colistin for five days or longer as IV antimicrobial therapy in patients with nosocomial infections Obtaining a written informed consent form from all patients or their guardians
Exclusion criteria
Exclusion criteria: Receive NAC less than 24 hours before the first dose of colistin Patients undergoing hemodialysis or peritoneal dialysis Receiving contrast material for radiological imaging Pregnant and lactating women Known allergy to colistin or N-acetylcysteine (NAC) Patient with recent history of cardiopulmonary resuscitation Patients with systolic blood pressure <90 mmHg GFR<60 ml/min
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary N-acetyl-beta-D glucosaminidase (NAG) level. Timepoint: First and fifth day of study. Method of measurement: Through the N-acetyl-beta-D glucosaminidase (NAG) urinary measurement kit.;Severity of kidney damage. Timepoint: Daily during the intervention period. Method of measurement: RIFLE classification system. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamideh abbaspour kasgari
Mazandaran University of Medical Sciences
Outcome results
None listed