Impact of letrozol on oocyte quality and IVF success

Impact of letrozol on improvement oocyte quality and IVF outcome in infertile patients underwent controlled ovarian stimulation

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200328046881N1

Enrollment

220

Registered

2020-04-05

Start date

2020-04-04

Completion date

Unknown

Last updated

2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Infertility. Condition 2: Infertility. Condition 3: Infertility. Condition 4: Infertility. Condition 5: Infertility. Condition 6: Infertility. Female infertility associated with anovulation Female infertility of tubal origin Female infertility of uterine origin Female infertility of other origin Female infertility, unspecified Encounter for male factor infertility in female patient

Interventions

Intervention 1: Intervention group: Simultaneous with introduce stimulation ovulation drugs , tablet letrozol 2.5 milligram (Iran hormone company )two time a day until trigger day will receive. Interv

Eligibility

Sex/Gender

Female

Age

17 Years to 40 Years

Inclusion criteria

Inclusion criteria: Infertile patient that IVF candidate with 40 years old or less use of antagonist protocol for IVF

Exclusion criteria

Exclusion criteria: Patient with cancer Use of IVF protocol except antagonist protocol

Design outcomes

Primary

Measure	Time frame
Number of metaphase 2 oocyte. Timepoint: After ovum pick up. Method of measurement: Number of metaphase 2 by counting metaphase 2 oocyte by embryologist.	—

Secondary

Measure	Time frame
Oocyte quality. Timepoint: After ovum pick up. Method of measurement: Based on morphology of different parts of metaphase 2 oocyte which determined by embryologist.;Oocyte maturation rate. Timepoint: After ovum pickup. Method of measurement: Number of metaphase2 oocytes divided to number of picked up oocytes.;Fertilization rate. Timepoint: After injection of sperm to metaphase 2 oocyte. Method of measurement: Number of 2PN divided to number of metaphase 2 oocyte that injected.;Clinical pregnancy rate. Timepoint: After embryo transfer. Method of measurement: Number of pregnancy that confirmed with presence of gestational sac in ultrasonography divided to number of fresh or frozen embryo transfer cycles.	—

Measure

Time frame

Oocyte quality. Timepoint: After ovum pick up. Method of measurement: Based on morphology of different parts of metaphase 2 oocyte which determined by embryologist.;Oocyte maturation rate. Timepoint: After ovum pickup. Method of measurement: Number of metaphase2 oocytes divided to number of picked up oocytes.;Fertilization rate. Timepoint: After injection of sperm to metaphase 2 oocyte. Method of measurement: Number of 2PN divided to number of metaphase 2 oocyte that injected.;Clinical pregnancy rate. Timepoint: After embryo transfer. Method of measurement: Number of pregnancy that confirmed with presence of gestational sac in ultrasonography divided to number of fresh or frozen embryo transfer cycles.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahin Bandarian

Tehran University of Medical Sciences

mahbandarianmd@ yahoo.com+98 21 6693 9320

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026