The effect of long-term use of vitamin C on pain reduction in patients with hand osteoarthritis

Investigation of the effect of long-term use of vitamin C on pain reduction in patients with hand osteoarthritis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200325046859N3

Enrollment

100

Registered

2021-01-12

Start date

2018-08-23

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

arthrosis. Other and unspecified osteoarthritis

Interventions

Intervention 1: Intervention group: Patients of the intervention group will receive Vitamin C produced by Avicenna corporation as a pain reliever with a daily dose of 1000 mg (four 250 mg chewable tab

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with hand osteoarthritis based on the American College of Rheumatology (ACR) criteria The Glomerular Filtration Rate (GFR) is more than 60 percent.

Exclusion criteria

Exclusion criteria: Patients with a history of kidney stone Patients with a history of kidney failure Drug addiction Use of any multivitamin, dietary and herbal supplements during the past two weeks before study.

Design outcomes

Primary

Measure	Time frame
Pain intensity. Timepoint: Before treatment, during treatment on a monthly basis, and after the end of treatment. Method of measurement: Using Visual Analogue Scale (VAS) and Australian/Canadian Hand Osteoarthritis Index (AUSCAN).;Serum levels of Vitamin C. Timepoint: Before and after intervention. Method of measurement: High-performance liquid chromatography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mandana Khodashahi

Mashhad University of Medical Sciences

khodashahimn@mums.ac.ir+98 51 3840 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026