The effect of naproxen on the healing process of patients with COVID-19

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200324046850N3

Enrollment

Registered

2020-03-30

Start date

2020-04-20

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

corona virus disease. COVID-19, virus not identified

Interventions

Intervention 1: Control group: Standard drugs of the national protocol (hydroxychloroquine sulfate 200mg, two single-dose tablets (Tehran Daru) , two single-dose tablets (Pars), Kaletra tablets (Lupin

Eligibility

Sex/Gender

All

Age

15 Years to No maximum

Inclusion criteria

Inclusion criteria: COVID-19 patients that have positive PCR test of nasopharyngeal sample or have positive CT Scan Having consent to participate in the intervention

Exclusion criteria

Exclusion criteria: pregnant or breast feeding women Those taking losartan and captopril. Those with a history of intestinal ulcers or gastrointestinal bleeding. Children under 14 years

Design outcomes

Primary

Measure	Time frame
Time to clinical improvement defined as start of taking medication time to the next 28 days. Timepoint: The beginning of the study ,the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: Medical record.	—

Secondary

Measure	Time frame
Duration of hospitalization. Timepoint: Time of discharge. Method of measurement: Number of hospital days.;Duration of stay at ICU. Timepoint: Daily. Method of measurement: Number of days of hospitalization in ICU.;Adverse events. Timepoint: Time of discharge. Method of measurement: Medical record.;Laboratory variables (CBC, CRP, BUN, Cr, AST, ALT, ALK-ph, ESR, CPK). Timepoint: The beginning of the study and the time of discharge. Method of measurement: Medical record.;Cough. Timepoint: The beginning of the study, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: Clinical observation and examination.;Shortness of breath. Timepoint: The beginning of the study, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: Clinical observation and examination.;Fatigue. Timepoint: The beginning of the study, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: Clinical observation and Interview with the patient.;Diarrhea. Timepoint: The beginning of the study, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: Interview with the patient.;Body pain. Timepoint: The beginning of the study, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: Interview with the patient.;The patient's condition is based on inpatient or outpatient. Timepoint: The beginning of the study, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: seven category ordinal scale.	—

Measure

Time frame

Duration of hospitalization. Timepoint: Time of discharge. Method of measurement: Number of hospital days.;Duration of stay at ICU. Timepoint: Daily. Method of measurement: Number of days of hospitalization in ICU.;Adverse events. Timepoint: Time of discharge. Method of measurement: Medical record.;Laboratory variables (CBC, CRP, BUN, Cr, AST, ALT, ALK-ph, ESR, CPK). Timepoint: The beginning of the study and the time of discharge. Method of measurement: Medical record.;Cough. Timepoint: The beginning of the study, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: Clinical observation and examination.;Shortness of breath. Timepoint: The beginning of the study, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: Clinical observation and examination.;Fatigue. Timepoint: The beginning of the study, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: Clinical observation and Interview with the patient.;Diarrhea. Timepoint: The beginning of the study, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: Interview with the patient.;Body pain. Timepoint: The beginning of the study, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: Interview with the patient.;The patient's condition is based on inpatient or outpatient. Timepoint: The beginning of the study, the seventh day, the fourteenth day, the twenty-first day, the twenty-eighth day. Method of measurement: seven category ordinal scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSara Mobarak

Abadan University of Medical Sciences

s.mobarak@abadanums.ac.ir+98 61 5338 4004

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026