The effect of simvastatin on healing of extracted tooth socket

Investigating the effect of simvastatin and collogen on the healing condition of extracted tooth socket (histomorphometric evaluation).

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200324046848N1

Enrollment

Registered

2020-12-03

Start date

2018-12-23

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Loss of teeth due to extractio. Complete loss of teeth

Interventions

Intervention 1: Intervention group: Simvastatin 10 mg and native collagen (Bone Protect Cone,Dentegris GmbH,Germany) in extracted tooth socket. Intervention 2: Control group: Receive native collagen

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: The patient with not restorable tooth or crown, a root fracture, extensive decay Residual roots without apical lesions Atraumatic tooth extraction People who are in complete health status

Exclusion criteria

Exclusion criteria: Smokers Pregnant and lactating women History of radiation therapy and chemotherapy Sensitivity to statin drugs

Design outcomes

Primary

Measure	Time frame
The healing of hard tissue of extracted tooth socket. Timepoint: At baseline and 8 weeks after surgery. Method of measurement: Amount of bone trabecule formed in the extracted tooth socket is measured in histologic specimen using ImageJ software.	—

Secondary

Measure	Time frame
Percentage of mineralized bone. Timepoint: 2 months after the surgery. Method of measurement: By histo-pathology evaluation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzane Vaziri

Yazd University of Medical Sciences

farzane.vaziri@gmail.com+98 913 156 3245

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026