Comparing the effectiveness of injectable pantoprazole, oral pantoprazole and injectable famotidine for stress ulcer prophylaxis in the intensive care unit.

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200322046833N3

Enrollment

Registered

2024-01-04

Start date

2023-10-23

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastric stress ulcer prophylaxes. Peptic ulcer, site unspecified

Interventions

Intervention 1: Intervention group: intravenous pantoprazole. Intervention 2: Intervention group: intravenous famotidine. Intervention 3: Intervention group: oral pantoprazole.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years of age hospitalized in the intensive care unit who have a nasogastric tube and are indicated for the prevention of peptic ulcer. Sign the informed consent

Exclusion criteria

Exclusion criteria: Bariatric surgery Gastrectomy surgery Active gastrointestinal ulcer or gastrointestinal bleeding Stomach malignancy Patients who have received PPI and H2 Blocker drugs in the last 5 days Patients whose gastric acid base is above 5

Design outcomes

Primary

Measure	Time frame
Frequency of occurrence of pH less than 5 during the study. Timepoint: On day 1,3,5 and 7 stomach pH of patients is determined by digital laboratory pH meter and paper pH meter (to avoid the optical error of litmus paper, it is confirmed by two people), 3 times a day. Method of measurement: about 10 cc of stomach contents are aspirated one hour after gavage and measured with digital laboratory pH meter and paper pH meter (to avoid the optical error of litmus paper, it is confirmed by two people).	—

Measure

Time frame

Frequency of occurrence of pH less than 5 during the study. Timepoint: On day 1,3,5 and 7 stomach pH of patients is determined by digital laboratory pH meter and paper pH meter (to avoid the optical error of litmus paper, it is confirmed by two people), 3 times a day. Method of measurement: about 10 cc of stomach contents are aspirated one hour after gavage and measured with digital laboratory pH meter and paper pH meter (to avoid the optical error of litmus paper, it is confirmed by two people).

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Secondary

Measure	Time frame
Average changes of CRP/Alb - lymphocyte to neutrophil ratio - platelet to lymphocyte ratio on the first day compared to the seventh day in the group of injectable famotidine and injectable pantoprazole and oral pantoprazole in patients admitted to the intensive care unit. The number of days hospitalized in the intensive care unit in the group of injectable famotidine and injectable pantoprazole and oral pantoprazole in patients hospitalized in intensive care units. Mortality in the group of injectable famotidine and parenteral pantoprazole and oral pantoprazole in patients admitted to the intensive care unit. Timepoint: The inflammatory index CRP/Alb is checked on day 0 and day 7. The time of discharge from the intensive care unit or the death of patients is recorded. Method of measurement: The inflammatory index CRP/Alb is checked on day 0 and day 7. The time of discharge from the intensive care unit or the death of patients is recorded.	—

Measure

Time frame

Average changes of CRP/Alb - lymphocyte to neutrophil ratio - platelet to lymphocyte ratio on the first day compared to the seventh day in the group of injectable famotidine and injectable pantoprazole and oral pantoprazole in patients admitted to the intensive care unit. The number of days hospitalized in the intensive care unit in the group of injectable famotidine and injectable pantoprazole and oral pantoprazole in patients hospitalized in intensive care units. Mortality in the group of injectable famotidine and parenteral pantoprazole and oral pantoprazole in patients admitted to the intensive care unit. Timepoint: The inflammatory index CRP/Alb is checked on day 0 and day 7. The time of discharge from the intensive care unit or the death of patients is recorded. Method of measurement: The inflammatory index CRP/Alb is checked on day 0 and day 7. The time of discharge from the intensive care unit or the death of patients is recorded.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarhad Najmeddin

Tehran University of Medical Sciences

f-najmeddin@sina.tums.ac.ir+98 21 6634 8500

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026