Treatment of COVID-19-induced cytokine storm by hemoperfusion

Treatment of COVID-19-induced cytokine storm with filter hemoperfusion HA330

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200317046797N5

Enrollment

Registered

2020-04-19

Start date

2020-04-20

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: COVID-19. Condition 2: COVID-19-induced pneumonia. COVID-19, virus identified Pneumonia due to SARS-associated coronavirus

Interventions

Intervention group: Patients undergo hemodialysis on 2 sessions, each session will be conducted in 4 hours using hemoperfusion HA330 filter (JAFRON BIOMEDICAL.CO.LTD, China). The second round will be

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Positive PCR for COVID-19 PaO2/FiO2 less than 200 mmHg More than 50% involvement of pulmonary fields in CT scan Respiratory rate more than 30/minute Resting O2 saturation less than 90%

Exclusion criteria

Exclusion criteria: Coagulation abnormality Plasma platelets count <30000/µL Other viral infection and bacterial sepsis Advanced multi-organ failure

Design outcomes

Primary

Measure	Time frame
The general condition of the patient. Timepoint: Before intervention and 1 day after final intervention. Method of measurement: Lung CT scan; No need to receive any intensive respiratory care in the patient.;Mortality rate. Timepoint: At baseline and discharge time or patient death. Method of measurement: Observation.;Need for intubation. Timepoint: Period of hospitalization. Method of measurement: Observation or reading of hospitalized documents.;Period of hospitalization. Timepoint: At baseline and discharge time. Method of measurement: Number of hospitalized days.	—

Measure

Time frame

The general condition of the patient. Timepoint: Before intervention and 1 day after final intervention. Method of measurement: Lung CT scan; No need to receive any intensive respiratory care in the patient.;Mortality rate. Timepoint: At baseline and discharge time or patient death. Method of measurement: Observation.;Need for intubation. Timepoint: Period of hospitalization. Method of measurement: Observation or reading of hospitalized documents.;Period of hospitalization. Timepoint: At baseline and discharge time. Method of measurement: Number of hospitalized days.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Taghizadieh

Tabriz University of Medical Sciences

alitaghizadieh@yahoo.com+98 41 1335 2078

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026