Intravenous immunoglobulin (IVIG) in the treatment of COVID-19-induced cytokine storm

To evaluate the effectiveness of intravenous immunoglobulin (IVIG) for the treatment of COVID-19-induced cytokine storm

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200317046797N3

Enrollment

100

Registered

2020-04-11

Start date

2020-04-20

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: COVID-19. Condition 2: Coronavirus (COVID-19)-induced pneumonia. U07.1: COVID-19, virus identified Pneumonia due to SARS-associated coronavirus

Interventions

Intervention 1: Intervention group: 50 patients with Coronavirus (COVID-19)-induced moderate or severe pneumonia in addition to the standard regimen of covid-19? will receive IVIG for 2 days (100-200

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Respiratory rate more than 30 PaO2/FiO2 less than 300 mm Hg Positive PCR for COVID -19 Age 18-65 year

Exclusion criteria

Exclusion criteria: Sensitivity to IVIG Pregnancy IgA deficiency syndrome

Design outcomes

Primary

Measure	Time frame
Improving the general condition of the patient. Timepoint: Before and after intervention. Method of measurement: Lung CT scan; No need to receive any intensive respiratory care in the patient.;Mortality rate. Timepoint: At baseline and discharge time or patient death. Method of measurement: Observation.;Need for intubation. Timepoint: Period of hospitalization. Method of measurement: Observation or reading of hospitalized documents.	—

Measure

Time frame

Improving the general condition of the patient. Timepoint: Before and after intervention. Method of measurement: Lung CT scan; No need to receive any intensive respiratory care in the patient.;Mortality rate. Timepoint: At baseline and discharge time or patient death. Method of measurement: Observation.;Need for intubation. Timepoint: Period of hospitalization. Method of measurement: Observation or reading of hospitalized documents.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Ardalan

Tabriz University of Medical Sciences

ardalan34@yahoo.com+98 41 3336 9331

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026