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Effect of HCG Injection in Frozen Thawed Embryo Transfer Cycls in Patients with Repeated Implanttion Failure

Comparison the Effect of intra Uterin and Intra Muscular HCG Injection 3 Days Before Transfer in frozen Thawed Embryo Transfer Cycls in Patients with Repeated Implantation Failure

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200305046702N1
Enrollment
210
Registered
2020-10-27
Start date
2020-06-20
Completion date
Unknown
Last updated
2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility. Female infertility

Interventions

Intervention 1: Intervention group : Endometrial preparation will be done for 20-40 years old infertile woman with recurrent implantation failure who are candidate for frozen thawed embryo transfer fr
when thickness reaches 7 mm ,they receive 500 unit intramuscular HCG along with 400 mg progesterone , 3 days before embryo transfer will be done. Intervention 2: Intervention group : Endometrial prep
when thickness reaches 7 mm ,they receive 500 unit intrauterine HCG along with 400 mg progesterone , 3 days before embryo transfer will be done.

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: 20-40 years old infertile patient with history of two or more previous impiantation failure candidate for frozen thawed embryo transfer

Exclusion criteria

Exclusion criteria: uterous malformation-sever endometriosis and adenomyosis-uterus adhesion- egg donation

Design outcomes

Primary

MeasureTime frame
Implantation. Timepoint: 4weaks after embryo transfer. Method of measurement: observation of gestational sacs by transvaginalultrasonography.;Chemical poregnancy. Timepoint: 2weaks after embryo transfer. Method of measurement: serum BHCG.

Secondary

MeasureTime frame
Clinical pregnancy. Timepoint: 2 weaks after positive BHCG. Method of measurement: vaginal sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Raziye Firouzabadi

Research and Clinical Center forInfertility? Shahid Sadoughi University of Medical Sciences

firouzabadi@ssu.ac.ir+98 35 1824 7085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026