Evaluating the Efficacy and Side Effects of Calcitonin in Enhancing Bone Union in Proximal Tibial Osteotomy: A Randomized double blind clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200305046700N9

Enrollment

Registered

2025-09-23

Start date

2025-10-07

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Proximal Tibial Osteotomy. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: Patients in both groups will be given the same antibiotics and painkillers (such as cefixime 200 mg and acetaminophen 100 mg) for 5 days after surgery. Patients in

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 18 to 50 years old HTO candidate for Varus correction MPTA = ??

Exclusion criteria

Exclusion criteria: History of previous lower limb surgery Thyroid disorders or bone pathologies History of dementia or psychiatric illness People who use corticosteroids or NSAIDs

Design outcomes

Primary

Measure	Time frame
The degree of bone union. Timepoint: weeks 4, 6, 8 after surgery. Method of measurement: By examining bone radiographs, a scale of four grades is used: no callus (score 1), minimal callus (score 2), significant callus (score 3), and complete union (score 4).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammadreza Razzaghof

Tehran University of Medical Sciences

m.razzaghof@gmail.com+98 21 6658 0196

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026