Knee Osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: oxandrolone 2.5 milligram tablets BID for 4 weeks post-op. Intervention 2: Intervention group: oxandrolone 10 milligram tablets BID for 4 weeks post-op. Interventio
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age 50 to 70 years Both sexes (male and female) Candidate for primary unilateral total knee replacement Ability to return for follow-up visits
Exclusion criteria
Exclusion criteria: Any previous history of knee surgery Severe endocrine disorders A history of cardiovascular, hepatic, hematological, respiratory, or peripheral vascular disease Active cancer A history of use of corticosteroids or anabolic steroids in the past 2 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quadriceps and Hamstring muscles volume. Timepoint: 0, 1, 3 months. Method of measurement: Ultrasonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| The Western Ontario and McMaster University Arthritis Index (WOMAC) is widely used in the assessment of hip and knee osteoarthritis. It includes 24 items that are divided into 3 subscales: pain (5 items) - stiffness (2 items) - physical function (17 items). Timepoint: 0,1,3 months. Method of measurement: questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mohammadreza Razzaghof
Tehran University of Medical Sciences
Outcome results
None listed