Investigating the effect of glutamine in colorectal surgery

Evaluation the effect of glutamine supplementation on inflammatory markers, surgical stress, carcinoembryonic antigen and postoperative outcomes in patients undergoing colorectal cancer surgery: a double-blind clinical trial study

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200301046655N3

Enrollment

200

Registered

2023-08-18

Start date

2023-07-27

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer. Malignant neoplasm of colon, unspecified

Interventions

Intervention 1: Intervention group: They will receive glutamine powder (Karen Company) in the form of 30 grams per day for 10 days before surgery. Intervention 2: Control group: They will receive plac

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists (ASA) classification = III Body mass index 18.5-30 Candidate for elective colorectal surgery

Exclusion criteria

Exclusion criteria: Absence of severe hepatic impairment Absence of renal impairment

Design outcomes

Primary

Measure	Time frame
Carcinoembryonic antigen. Timepoint: At the beginning of the study (10 days before surgery), and one month after surgery. Method of measurement: Quantitative electroluminescence.	—

Secondary

Measure	Time frame
Interleukin 6. Timepoint: At the beginning of the study (10 days before surgery), 12 hours before surgery and 48 hours after surgery. Method of measurement: Elisa method test.;Neutrophil to lymphocyte ratio. Timepoint: At the beginning of the study (10 days before surgery), 12 hours before surgery and 48 hours after surgery. Method of measurement: The ratio of blood neutrophils to blood lymphocytes.;Complications after surgery. Timepoint: During the first month after surgery. Method of measurement: Classification of complications based on Clavin-Dindo criteria.;Average ratio of lymphocytes to monocytes. Timepoint: At the beginning of the study (10 days before surgery), 12 hours before surgery and 48 hours after surgery. Method of measurement: The ratio of lymphocyte to monocyte.;Reactive protein c. Timepoint: At the beginning of the study (10 days before surgery), 12 hours before surgery and 48 hours after surgery. Method of measurement: Immunoturbidometry method.	—

Measure

Time frame

Interleukin 6. Timepoint: At the beginning of the study (10 days before surgery), 12 hours before surgery and 48 hours after surgery. Method of measurement: Elisa method test.;Neutrophil to lymphocyte ratio. Timepoint: At the beginning of the study (10 days before surgery), 12 hours before surgery and 48 hours after surgery. Method of measurement: The ratio of blood neutrophils to blood lymphocytes.;Complications after surgery. Timepoint: During the first month after surgery. Method of measurement: Classification of complications based on Clavin-Dindo criteria.;Average ratio of lymphocytes to monocytes. Timepoint: At the beginning of the study (10 days before surgery), 12 hours before surgery and 48 hours after surgery. Method of measurement: The ratio of lymphocyte to monocyte.;Reactive protein c. Timepoint: At the beginning of the study (10 days before surgery), 12 hours before surgery and 48 hours after surgery. Method of measurement: Immunoturbidometry method.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRazieh Khalooeifard

Tehran University of Medical Sciences

shkhalooei1367@gmail.com+98 21 6634 8500

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026