The comparison effect of dexmedetomidine and propofol during laparoscopic cholecystectomy

The comparison effect of dexmedetomidine and propofol on hemodynamics parameters and stress response hormones during laparoscopic cholecystectomy in patients referred to Razi Hospital in 2019-2020

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200225046610N1

Enrollment

Registered

2020-12-15

Start date

2020-03-20

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

laparoscopic cholecystectomy patients. Calculus of bile duct with cholecystitis, unspecified, without obstruction

Interventions

Intervention 1: intervention group 1: To induce anesthesia in both groups, a combination of midazolam (Caspian CO.)(0.05 mg / kg), fentanyl (Caspian CO.) (2 µg / kg), thiopental sodium (VUAB pharma CO

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: The patients between 20 to 60 age years old The candidate patients for laparoscopic cholecystectomy

Exclusion criteria

Exclusion criteria: The patients have class II or III obesity Chronic liver disease Diabetes Kidney disease Endocrine problems Romatoid disease The cardiovascular disease patients which use a beta-blocker drug that affects sympathies response and hormonal secretion and finally The person uses benzo diazepines are excluded from this study

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: At the beginning and end of the study. Method of measurement: Anesthesia Monitoring system.;Mean atrial blood pressure (MAP). Timepoint: At the beginning and end of the study. Method of measurement: Anesthesia Monitoring system.;Duration of anesthesia. Timepoint: At the beginning and end of the study. Method of measurement: Extraction of patient anesthesia sheet.;Plasma level of blood sugar. Timepoint: At the beginning and end of the study. Method of measurement: Lab by specto-photometery method.;Level of stress hormone (epinephrine, nor-epinephrine, cortisol). Timepoint: At the beginning and end of the study. Method of measurement: Lab by ELISA method.	—

Measure

Time frame

Heart rate. Timepoint: At the beginning and end of the study. Method of measurement: Anesthesia Monitoring system.;Mean atrial blood pressure (MAP). Timepoint: At the beginning and end of the study. Method of measurement: Anesthesia Monitoring system.;Duration of anesthesia. Timepoint: At the beginning and end of the study. Method of measurement: Extraction of patient anesthesia sheet.;Plasma level of blood sugar. Timepoint: At the beginning and end of the study. Method of measurement: Lab by specto-photometery method.;Level of stress hormone (epinephrine, nor-epinephrine, cortisol). Timepoint: At the beginning and end of the study. Method of measurement: Lab by ELISA method.

—

Secondary

Measure	Time frame
Post operative nausea and vomiting (PONV). Timepoint: After release of recovery room each 6 Hr. Method of measurement: Sensation of nausea and vomiting by Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzad Khalvati

Ahvaz University of Medical Sciences

khalvatifarzad@gmail.com+98 61 6475 9841

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026