The effect of herbal mouthwash on oral mucositis in children with leukemia under chemotherapy

Comparison the effect of aloe vera and honey mouthwash on oral mucositis caused by chemotherapy in children with leukemia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200222046582N1

Enrollment

100

Registered

2020-05-20

Start date

2020-05-21

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oral chemotherapy for leukemia in children with leukemia. Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Interventions

Intervention 1: The intervention group is divided into three groups: the first group: honey mouthwash, the second group: aloe vera mouthwash, the third group: mouthwash combining aloe vera and honey).

Eligibility

Sex/Gender

All

Age

6 Years to 18 Years

Inclusion criteria

Inclusion criteria: Completion of written consent by the child or the child's guardian parent (based on the child's age) for the child's participation in the study Having a child has the necessary ability and cooperation to participate in the study Lack of systemic problems (kidney, liver, etc.) or other malignancies Food allergies or known allergies to aloe vera Lack of diabetes and no history of hyperglycemia The child has oral health before starting chemotherapy (no mucositis) Do not use other mouthwashes during treatment, do not use painkillers continuously, do not use antibiotics

Exclusion criteria

Exclusion criteria: Children undergoing radiotherapy in addition to chemotherapy Children who refuse to continue their studies Patients with neutropenia, fever, gingivitis Teens who smoke and smoke hookah Use of steroidal anti-inflammatory drugs

Design outcomes

Primary

Measure	Time frame
During the first, seventh, fourteenth, twenty-first days after chemotherapy with the help of a researcher examining inflammation of the oral mucosa using the Ilers tool and the oral cavity condition using the WHO tool, aswell as the pain caused by mucositis (by the child) using the VAS tool And the question of the child who has experienced the most pain during the day? All 4 groups under study will be reviewed and recorded. Timepoint: During the first, seventh, fourteenth and twenty-first days after chemotherapy. Method of measurement: With the help of a researcher examining inflammation of the oral mucosa using the Ilers tool and the oral cavity condition using the WHO moucositis scale tool, as well as pain caused by mucositis (by the child) using the tool and Visual Analogue Scale ask the child which pain is most common during the day. Experienced? All 4 groups under study will be reviewed and recorded.	—

Measure

Time frame

During the first, seventh, fourteenth, twenty-first days after chemotherapy with the help of a researcher examining inflammation of the oral mucosa using the Ilers tool and the oral cavity condition using the WHO tool, aswell as the pain caused by mucositis (by the child) using the VAS tool And the question of the child who has experienced the most pain during the day? All 4 groups under study will be reviewed and recorded. Timepoint: During the first, seventh, fourteenth and twenty-first days after chemotherapy. Method of measurement: With the help of a researcher examining inflammation of the oral mucosa using the Ilers tool and the oral cavity condition using the WHO moucositis scale tool, as well as pain caused by mucositis (by the child) using the tool and Visual Analogue Scale ask the child which pain is most common during the day. Experienced? All 4 groups under study will be reviewed and recorded.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactLaya Rabiee

Mashhad University of Medical Sciences

www.rabieel1@mums.ac.ir+98 51 3662 4162

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026