Head injury. traumatic intracerebral haemorrhage , Epidural haemorrhage Extradural haemorrhage (traumatic), Traumatic subdural haemorrhage
Conditions
Interventions
Intervention 1: Intervention group: had received the initial dosage of 1 gram tranexamic acid within the first 3 hours of admission, and afterwards 1 gram every 6 hours for 48 hours. Intervention 2: C
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: The age above 18 years old The existence of hemorrhage in brain CT scan including subdural hematoma, epidural hematoma, intracerebral hemorrhage and intraventricular hemorrhage less than 8 hours passed from trauma The absence of coagulopathy
Exclusion criteria
Exclusion criteria: patients with GCS of 3 macroscopic hematuria history of anticoagulant medication active vascular thrombosis or a history of it hypercoagulative state congenital or acquired hypercoagulopathy history of vascular disease valvular heart disease renal failure diabetes mellitus pregnancy or breastfeeding periods history of allergic reaction to TXA history of seizure history of brain stroke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain hemorrhage volume. Timepoint: diameter and volume of traumatic intracerebral hemorrhage before intervention and 6, 24 , 48 hours after intervention. Method of measurement: Volume in ml of blood in the brain CT scan on the hospital's network. It calculate by multiplying the maximum length in maximum width in number of cuts of hemorrhage in centimeter divided by the 2,and registering on designed form. | — |
Secondary
| Measure | Time frame |
|---|---|
| Level of consciousness. Timepoint: upon admission and discharge. Method of measurement: Glasgow coma scale.;Midline shift. Timepoint: before intervention and 6, 24 , 48 hours after intervention. Method of measurement: spiral brain CT scan. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHosein safari
Ahvaz University of Medical Sciences
Outcome results
None listed